Valery Belakhov Selected Research

Cystic Fibrosis (Mucoviscidosis)

6/2023	Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases.
4/2016	Design of Novel Aminoglycoside Derivatives with Enhanced Suppression of Diseases-Causing Nonsense Mutations.
4/2014	Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.
11/2011	Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54.
6/2010	Repairing faulty genes by aminoglycosides: development of new derivatives of geneticin (G418) with enhanced suppression of diseases-causing nonsense mutations.
5/2009	Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

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Valery Belakhov Research Topics

Disease

11	Inborn Genetic Diseases (Disease, Hereditary) 06/2023 - 05/2009
6	Cystic Fibrosis (Mucoviscidosis) 06/2023 - 05/2009
6	Mucopolysaccharidosis I (Hurler Syndrome) 04/2016 - 05/2009
4	Usher Syndromes (Usher Syndrome) 06/2023 - 05/2009
2	Ototoxicity 04/2014 - 01/2014
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2014 - 01/2012
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 06/2010 - 05/2009
1	Neoplasms (Cancer) 01/2017
1	Glucose Intolerance 03/2016
1	Body Weight (Weight, Body) 03/2016
1	Leishmaniasis 09/2015
1	Visceral Leishmaniasis (Kala Azar) 09/2015
1	Disease Progression 03/2014
1	Rett Syndrome (Rett's Disorder) 04/2011

Drug/Important Bio-Agent (IBA)

12	Nonsense Codon (Nonsense Mutation)IBA 06/2023 - 05/2009
10	AminoglycosidesIBA 06/2023 - 05/2009
5	Gentamicins (Gentamicin)FDA LinkGeneric 01/2017 - 05/2009
4	DNA (Deoxyribonucleic Acid)IBA 06/2023 - 05/2009
3	Iduronidase (alpha-L-Iduronidase)IBA 03/2014 - 01/2012
2	antibiotic G 418IBA 01/2017 - 03/2013
2	Anti-Bacterial Agents (Antibiotics)IBA 09/2015 - 03/2013
1	gamma-Aminobutyric Acid (GABA)IBA 03/2016
1	Glucose (Dextrose)FDA LinkGeneric 03/2016
1	Paromomycin (Paromomycin Sulfate)FDA LinkGeneric 09/2015
1	Proteins (Proteins, Gene)FDA Link 01/2014
1	GlycosaminoglycansIBA 01/2012

Therapy/Procedure

5	Therapeutics 01/2017 - 04/2011